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Robert W. Stackman, Jr.

Dr.Stackman

  • Associate Vice President for the Jupiter Campus and Professor
  • Department of Psychology
  • 561-799-8052 (Jupiter); 561-297-4358 (Boca)
  • rstackma@fau.edu
  • Jupiter - MC-19(RE), 101

Education

Ph.D., Rutgers, The State University of New Jersey
NIH NRSA Grant Trainee and Postdoctoral Fellow, Dartmouth College

Research Interests

  • Cellular and circuit mechanisms of long-term memory
  • Spatial navigation and limbic system networks
  • Behavioral (in-vivo) neurophysiology
  • Hippocampal and cortical interactions and coding of object memory

Research Description

Our lab focuses on several interconnected projects aimed at understanding the brain circuits and cellular mechanisms that support long-term memory in mammals. We work under the hypothesis that significant experiences or events are organized in the nervous system as memories of items or objects and their spatial context. A key aspect of this organization is the integration of parallel streams of information within the hippocampus and the broader hippocampal formation.

One project explores how specific cortical regions contribute to memory for objects and context, and how novel experiences enhance the consolidation of these memories. Another project maps neurons within memory circuits by examining the behavioral correlates of their firing properties. Additionally, we investigate how neurons coding for spatial location and directional heading assist in spatial problem-solving. Finally, we examine the influence of SK-type potassium channels on behavior and synaptic plasticity, both in young, healthy animals and in a pharmacological model of schizophrenia-like behavior.

Together, these projects aim to provide new insights into memory organization and how neurophysiological representations of memory attributes guide memory retrieval and problem-solving.

Current students:
Marli Knox, Honors thesis student at Wilkes Honors College
Dheeraj Ayapati, Honors thesis student at Wilkes Honors College
Alcira Munchow, Ph.D. student in Integrative Biology - Neuroscience
Anastasia Tyulmenkova, Ph.D. student in Integrative Biology - Neuroscience

Lab Alumni:
Brittany Crafton, MA in Psychology (2023)
Claire A. Rice, Ph.D. in Experimental Psychology (2021)
David Cinalli, Ph.D. in Experimental Psychology (2020)
Brandon Hindman, MA in Psychology (2019)
Gongliang Zhang, Postdoctoral Fellow (2010-2012; 2017-18)
Herborg Nanna Ásgeirsdóttir, Ph.D. in Integrative Biology - Neuroscience (2017)
Joan C. Lora, Ph.D. in Integrative Biology - Neuroscience (2017)
Sarah J. Cohen, Ph.D. in Complex Systems & Brain Sciences (2016)
Shannon Sanguinetti, MS in Biology (2015)
Lisa S. Rios, MA in Psychology (2011)
Rebecca Lee, MS in Biomedical Science (2010)
Meltem Ballan, Ph.D. in Complex Systems & Brain Sciences (2010)
Kyle Vick, MA in Psychology (2009)
Sidney Williams, MA in Psychology (2009)
Eric Buerger, MA in Psychology (2008)
Rebecca S. Hammond, Ph.D. in Behavioral Neuroscience (2005, Oregon Health & Science University)

Recent Publications (* denotes undergraduate author)

  • Rice CA and Stackman Jr RW (2024) The small conductance calcium-activated K+ channel activator, GW542573X impairs hippocampal memory in C57BL/6J mice. Neuropharmacology, 252: 109960. https://doi.org/10.1016/j.neuropharm.2024.109960
  • Cinalli Jr, DA, Cohen SJ, *Calubag M, *Oz G, *Zhou L and Stackman Jr RW (2023) DREADD-inactivation of dorsal CA1 pyramidal neurons in mice impairs retrieval of object and spatial memories. Hippocampus, 33(1): 6-17. doi: 10.1002/hipo.23484
  • Bunner W, Wang J, Cohen SJ, Bashtovyy D, Perry R., Shookster D, Landry T, Harris EM, Stackman Jr RW, Tran T, Yasuda R and Szatmari EM (2023) Behavioral and transcriptome profiling of Rab10 knockout mice. eNeuro,10(5): ENEURO.0459-22.2023 doi: 10.1523/ENEURO.0459-22.2023
  • Cohen SJ, Cinalli Jr DA, Ásgeirsdóttir HN, Hindman B, Barenholtz E and Stackman Jr RW (2022) Mice recognize 3D objects from recalled 2D pictures, support for picture-object equivalence. Scientific Reports, 12(1): 4184. DOI: 10.1038/s41598-022-07782-4 
  • Cinalli Jr DA, Cohen SJ, Guthrie K and Stackman Jr RW (2020) Object recognition memory: Distinct yet complementary roles of the mouse CA1 and perirhinal cortex. Frontiers in Molecular Neuroscience, 13: 527543. doi/10.3389/fnmol.2020.527543
  • Szatmari E, Moran C, Cohen SJ, Jacob A, Parra-Bueno P, Kamasawa N, Guerrero-Given D, Klein M, Stackman Jr RW, and Yasuda R (2020) ADAP1/Centaurin-α1 negatively regulates dendritic spine function and memory formation in the hippocampus. eNeuro, Nov 2: ENEURO.0111-20.2020. doi/10.1523/ENEURO.0111-20.2020
  • Ásgeirsdóttir HN, Cohen SJ and Stackman Jr RW (2020) Object and place information processing by CA1 hippocampal neurons of C57BL/6J mice. Journal of Neurophysiology,  123(3): 1247-1264. doi/full/10.1152/jn.00278.2019
  • Song Y, Zhu J-S, Hua R, Du L, Huang S-T, Stackman Jr RW, Zhang G and Zhang Y-M (2018) Small conductance Ca2+-activated K+ channel 2 (SK2) in spinal dorsal horn participates in visceral hypersensitivity induced by neonatal colorectal distension in rats. Frontiers in Pharmacology, 9(840) https://doi.org/10.3389/fphar.2018.00840
  • Zhang G, Cinalli Jr DA and Stackman Jr RW (2017) Effect of a hallucinogenic serotonin 5-HT2A receptor agonist on visually-guided hippocampal-dependent spatial cognition in C57BL/6J mice. Hippocampus, 27(5): 558-569. doi/full/10.1002/hipo.22712
  • Stackman Jr RW, Cohen SJ, Lora JC and Rios LM (2016) Temporary inactivation reveals that the CA1 region of the dorsal hippocampus plays an equivalent role in the retrieval of long-term object memory and spatial memory. Neurobiology of Learning and Memory, 133: 118-128. doi/10.1016/j.nlm.2016.06.016
  • Zhang G, Cinalli Jr DA, Cohen SJ, *Knapp KD, Rios LM, Martinez-Hernandez J, Lujan R and Stackman Jr RW (2016). Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57B/6J mice. Neuropharmacology,  109: 332-340. doi/10.1016/j.neuropharm.2016.04.033
  • Cohen SJ and Stackman Jr RW (2015). Assessing rodent hippocampal involvement in the novel object recognition task. A review. Behavioural Brain Research, 285: 105-117. doi/10.1016/j.bbr.2014.08.002
  • Cohen SJ, Munchow A, Rios LM, Zhang G, Ásgeirsdóttir HN and Stackman Jr RW (2013). The rodent hippocampus is essential for non-spatial object memory. Current Biology. 23: 1685-1690. https://doi.org/10.1016/j.cub.2013.07.002

Scholarly Activites

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BobLab 2019 (l-r): Brittany Crafton (MA 2023); Claire Rice (Ph.D. 2020); Brandon Hindman (MA 2019); RWS, Sarah Cohen (Ph.D. 2016); David Cinalli, (Ph.D. 2020); Goksu Oz (B.S. 2019)
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